Notch Inhibition via Micro-RNA Blocks Glioma Development
نویسندگان
چکیده
منابع مشابه
Notch inhibition via micro-RNA blocks glioma development.
required to safely and completely assess the patient’s status and eligibility for IV tPA. Third, a remote exam does not replace the physical presence of a physician from a clinical point of view and from a physician-patient relationship perspective. That physical presence at bedside is essential to build trust and therefore to allow the patient and the physician alike to make confident assured ...
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PURPOSE Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and remains refractory to combined-modality therapy in patients with high risk disease. In skeletal myogenesis, Notch signaling prevents muscle differentiation and promotes proliferation of satellite cell progeny. Given its physiologic role in myogenesis and oncogenic role in other human cancers, we hypothesized ...
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Glioma is the most common type of primary intracranial tumor and is highly lethal due to its pathogenetic location, high invasiveness, and poor prognosis. Even combined surgery and chemoradiotherapy do not effectively rescue glioma patients. Molecular target therapy is considered a safe and promising therapy for glioma. The identification of a novel, effective target protein in gliomas is of gr...
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Targeting self-renewal is an important goal in cancer therapy and recent studies have focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs). Understanding cancer-specific Notch regulation would improve specificity of targeting this pathway. In this study, we find that Notch1 activation in GSCs specifically induces expression of the lncRNA, TUG1. TUG1 coordinatel...
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The Notch signaling pathway is required in both nonneoplastic neural stem cells and embryonal brain tumors, such as medulloblastoma, which are derived from such cells. We investigated the effects of Notch pathway inhibition on medulloblastoma growth using pharmacologic inhibitors of gamma-secretase. Notch blockade suppressed expression of the pathway target Hes1 and caused cell cycle exit, apop...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2012
ISSN: 0148-396X
DOI: 10.1227/01.neu.0000413225.95714.c9